Warhol was born on August 6, 1928, in Pittsburgh, Pennsylvania. He was the fourth child of Ondrej Warhola (Americanized as Andrew Warhola, Sr., 1889–1942) and Julia (née Zavacká, 1892–1972),[11] whose first child was born in their homeland of Austria-Hungary and died before their move to the U.S.

Warhol's early career was dedicated to commercial and advertising art, where his first commission had been to draw shoes for Glamour magazine in the late 1940s. In the 1950s, Warhol worked as a designer for shoe manufacturer Israel Miller. While working in the shoe industry, Warhol developed his "blotted line" technique, applying ink to paper and then blotting the ink while still wet, which was akin to a printmaking process on the most rudimentary scale. His use of tracing paper and ink allowed him to repeat the basic image and also to create endless variations on the theme.

Warhol was an early adopter of the silk screen printmaking process as a technique for making paintings. In 1962, Warhol was taught silk screen printmaking techniques by Max Arthur Cohn at his graphic arts business in Manhattan. In his book Popism: The Warhol Sixties, Warhol writes: "When you do something exactly wrong, you always turn up something."

In May 1962, Warhol was featured in an article in Time magazine with his painting Big Campbell's Soup Can with Can Opener (Vegetable) (1962), which initiated his most sustained motif, the Campbell's soup can. That painting became Warhol's first to be shown in a museum when it was exhibited at the Wadsworth Atheneum in Hartford in July 1962. On July 9, 1962, Warhol's exhibition opened at the Ferus Gallery in Los Angeles with Campbell's Soup Cans, marking his West Coast debut of pop art.

In November 1962, Warhol had an exhibition at Eleanor Ward's Stable Gallery in New York. The exhibit included the works Gold Marilyn, eight of the classic "Marilyn" series also named "Flavor Marilyns", Marilyn Diptych, 100 Soup Cans, 100 Coke Bottles, and 100 Dollar Bills. Gold Marilyn, was bought by the architect Philip Johnson and donated to the Museum of Modern Art. At the exhibit, Warhol met poet John Giorno, who would star in Warhol's first film, Sleep (1964).